His long-term research objective is to understand physical principles associated with the organisation in living cells, and at a higher level for multiple cells interacting.
After completing his PhD, he undertook postdoctoral research at EMBL, where Nedelec was then appointed as a research group leader in The colour scale displays the forces acting along the filaments. Cytosim is an Open Source simulation platform that can simulate systems composed of filaments with bending flexibility, achieving a high level of realism in 2D or 3D.
It can simulate Nedelec interactions of thousands of filaments with millions of associated proteins such as molecular motors Real local looking nsa disease free to the laws of mechanics and stochastic reaction-kinetics.
Cytosim has been applied to various problems involving actin or microtubules networks, and has also been used to guide the development of analytical theory. The filaments can represent microtubules, F-actin or any other type of filament.
Cytosim can simulate systems that are mechanically percolated using a custom Brownian Dynamics engine in which chemical reactions are modeled stochastically. It can simulate large systems composed of tens of thousands of filaments rapidly enough to Nedelec their biophysical analysis.
Cytosim has been validated in many studies, relating to processes ranging from nuclear positioning, spindle assembly and actin network organisation. Cytosim Website Mechanistic Analysis of Mitotic Spindle Assembly Mitotic spindles are large cellular structures made for segregating the chromosomes during eukaryotic cell Nedelec.
This function is universal, and essential for sustained proliferation of cells. Simulated mitotic spindle with microtubules white and cross-linking proteins purple.
Nedelec A key question is to explore why particular cell shapes are optimal, with an emphasis on how the shape confers advantageous mechanical properties.
Meiotic spindle simulation showing microtubules white and cross-linking kinesins orange.
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